About Jasper

Jasper is a clinical-stage biotechnology company developing briquilimab, a monoclonal antibody targeting c-Kit (CD117) as a therapeutic for chronic mast and stem cell diseases such as chronic urticaria and lower to intermediate risk myelodysplastic syndromes (MDS) and as a conditioning agent for stem cell transplants for rare diseases such as sickle cell disease (SCD), Fanconi anemia (FA) and severe combined immunodeficiency (SCID). To date, briquilimab has a demonstrated efficacy and safety profile in over 130 dosed subjects and healthy volunteers, with clinical outcomes as a conditioning agent in SCID, acute myeloid leukemia (AML), MDS, FA, and SCD. In addition, briquilimab is being advanced as a transformational non-genotoxic conditioning agent for gene therapy.

Our novel mRNA stem cell graft platform is intended to address the limitations of transplant grafts and unlock the potential of stem cells, expanding the number of patients who could benefit from allogeneic and autologous gene edited hematopoietic stem cell therapy.

Our History

Jasper Therapeutics was founded by Dr. Judith Shizuru, a Stanford professor, and Dr. Susan Prohaska, a Stanford-trained immunology and stem cell scientist and drug developer, with the goal of bringing curative hematopoietic stem cell transplantation and gene therapies to more people by making them safer and more effective. Building on niche-clearing technology from Stanford, Dr. Shizuru initiated a clinical program funded by the California Institute for Regenerative Medicine (CIRM) with $23M in grant support to safely condition patients prior to hematopoietic stem cell transplantation.

Jasper unites technologies from Stanford University and Amgen with cutting-edge science and expertise in hematopoietic stem cell transplantation, stem cell biology, oncology and drug development. Jasper has acquired worldwide rights to Briquilimab (Formerly JSP191) from Amgen, which originally discovered JSP191 (formerly AMG191), as well as translational science and materials from Stanford University.

Jasper Therapeutics was launched with $50M in Series A financing. Abingworth LLP and Qiming Venture Partners USA served as lead investors, with further investment from Surveyor Capital (a Citadel company), Alexandria Venture Investments, LLC and Roche Venture Fund.